Serotonin involvement in Rhodiola rosea attenuation of nicotine withdrawal signs in rats.

Rhodiola rosea has been used for centuries in the traditional medicine to stimulate nervous system, to enhance physical and mental performance and to treat fatigueFatigueMajor cause of disability in primary Sjögren's syndrome (pSS). It is known that administration of Rhodiola rosea extract elicits antidepressant activity, but the mechanism of action still remains unclear. Evidence from animal models and human studies show that nicotine reduces symptoms of depressionDepressionCaused by a repetitive experience of loss of control resulting in internal, stable and global attributional styles for negative events and that nicotine cessation induces depressive-like symptoms. We investigated the effects of Rhodiola rosea on nicotine withdrawal signs. Nicotine dependence was induced by subcutaneous nicotine injection (2mg/kg, four times daily) for 14 days. Another group of animals treated with nicotine (for 14 days) and successively with Rhodiola rosea extract was co-administered with selective 5-HTSerotoninNeuromodulator affecting myriad aspects of personality and behavior and has been implicated in the pathophysiology of affective disorders including depression and anxiety receptorial antagonist WAY 100635 (1mg/kg). After nicotine withdrawal animals were evaluated for behavioural parameters (locomotor activity, abstinence signs, marble burying test), diencephalic serotoninSerotoninNeuromodulator affecting myriad aspects of personality and behavior and has been implicated in the pathophysiology of affective disorders including depression and anxiety metabolism and serotoninSerotoninNeuromodulator affecting myriad aspects of personality and behavior and has been implicated in the pathophysiology of affective disorders including depression and anxiety receptor-1A expression. ResultsResultsSituated at the depression site distal to the second metacarpophalangeal joint on the radial side show a significant increase of 5-HTSerotoninNeuromodulator affecting myriad aspects of personality and behavior and has been implicated in the pathophysiology of affective disorders including depression and anxiety content in N treated with R. rosea, with a significant increase of serotoninSerotoninNeuromodulator affecting myriad aspects of personality and behavior and has been implicated in the pathophysiology of affective disorders including depression and anxiety receptor 1A, suggesting an involvement of serotoninSerotoninNeuromodulator affecting myriad aspects of personality and behavior and has been implicated in the pathophysiology of affective disorders including depression and anxiety in beneficial effects of R. rosea on suffering produced by nicotine withdrawal.

Published In:

Phytomedicine : international journal of phytotherapy and phytopharmacology • Aug 23, 2012

Authors & Affiliation:

Calapai, G; Caputi, A P; Calzavara, E; Navarra, M; Mannucci, C
Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology, School of Medicine, University of Messina, Italy.

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Terminology Definitions on this Page

What's This?Terminology definitions come from medical journal articles which appear in this category.

Depression
Caused by a repetitive experience of loss of control resulting in internal, stable and global attributional styles for negative events

Fatigue
Major cause of disability in primary Sjögren's syndrome (pSS)

Results (LI 2)
Situated at the depression site distal to the second metacarpophalangeal joint on the radial side

Serotonin (5-HT)
Neuromodulator affecting myriad aspects of personality and behavior and has been implicated in the pathophysiology of affective disorders including depression and anxiety

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